Semaglutide: as the comparator

69 studies: what is tested is compared with it. Page 1 of 1. Open to participants first (33), then studies with results posted, then the rest; newest registration first within each.

• A Research Study Investigating How Well Zenagamtide at Lower Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide at Lower Dose Levels in People With Type 2 Diabetes Treated With Metformin, Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i), or BothNot yet recruitingNCT07931599Phase 3Report a problem
• AMBITION 3: A Research Study Investigating How Well Zenagamtide at Higher Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide in People With Type 2 Diabetes Treated With Metformin, SGLT2i, or BothNot yet recruitingNCT07931573Phase 3Report a problem
• A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and ObesityNot yet recruitingNCT07919405Phase 3Report a problem
• Maridebart Cafraglutide Versus Semaglutide in Participants With Type 2 DiabetesRecruitingNCT07866066Phase 3Report a problem
• A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or ObesityRecruitingNCT07845500Phase 3Report a problem
• A Study Evaluating Safety and Tolerability of Switching From Semaglutide to Zovaglutide in Adults With Obesity (HORIZON-SWITCH-SZ)Not yet recruitingNCT07812597Phase 2Report a problem
• Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes MellitusRecruitingNCT07801820Phase 2Report a problem
• A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or ObesityRecruitingNCT07767175Phase 1Report a problem
• A Study of BGM0504 in Early T2DM With ObesityRecruitingNCT07743983Phase 3Report a problem
• Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With SemaglutideNot yet recruitingNCT07713992Not applicableReport a problem
• A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to SemaglutideRecruitingNCT07668414Phase 3Report a problem
• A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 DiabetesRecruitingNCT07668388Phase 2Report a problem
• A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusRecruitingNCT07662213Phase 3Report a problem
• Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)RecruitingNCT07653477Phase 3Report a problem
• BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 DiabetesNot yet recruitingNCT07628985Phase 3Report a problem
• BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or ObesityNot yet recruitingNCT07622810Phase 3Report a problem
• Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 DiabetesNot yet recruitingNCT07487103Phase 3Report a problem
• A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesRecruitingNCT07415954Phase 2Report a problem
• Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 DiabetesRecruitingNCT07317115Not applicableReport a problem
• Epicardial Cardiac Fat-CT (EPIC-CT)RecruitingNCT07297589Phase 3Report a problem
• Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes MellitusNot yet recruitingNCT07187856Phase 2Report a problem
• Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight SubjectsRecruitingNCT07150975Phase 3Report a problem
• A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 DiabetesNot yet recruitingNCT07139548Phase 3Report a problem
• A Study to Compare Different Doses of Tifeglipron (RO7795081) With Placebo or Semaglutide in People With Type 2 DiabetesRecruitingNCT07112872Phase 2Report a problem
• Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver DiseaseRecruitingNCT07058155Phase 4Report a problem
• Metabolic Surgery for Atrial Fibrillation EliminationNot yet recruitingNCT07027969Phase 4Report a problem
• The Role of the Amylin Analogue Cagrilintide in Bone MetabolismRecruitingNCT07010432Phase 1Report a problem
• Probiotic Intervention on Body WeightRecruitingNCT06989177Not applicableReport a problem
• The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and ObesityRecruitingNCT06830343Phase 1Report a problem
• A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney DiseaseRecruitingNCT06717698Phase 2Report a problem
• Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshNot yet recruitingNCT06449235Phase 4Report a problem
• Effectiveness of Weight Loss Methods on Lifespan for Metabolic SyndromeRecruitingNCT06410352Phase 4Report a problem
• Fibrosis Lessens After Metabolic SurgeryRecruitingNCT06374875Phase 4Report a problem
• A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With MetforminCompletedNCT06045221Phase 3Results postedReport a problem
• A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related ComorbiditiesCompletedNCT05822830Phase 3Results postedReport a problem
• A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity RangeTerminatedNCT05671653Phase 1Results postedReport a problem
• Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With ObesityTerminatedNCT05579977Phase 2Results postedReport a problem
• A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2)CompletedNCT05259033Phase 3Results postedReport a problem
• A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)CompletedNCT04944992Phase 2Results postedReport a problem
• A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes MellitusCompletedNCT04515849Phase 2Results postedReport a problem
• A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes.CompletedNCT04153929Phase 2Results postedReport a problem
• A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 DiabetesCompletedNCT03987919Phase 3Results postedReport a problem
• A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM)CompletedNCT03951753Phase 1Results postedReport a problem
• A Study Comparing the Effects of BGM0504 Injection and Semaglutide Injection on Obese Subjects.CompletedNCT07836140Phase 2Report a problem
• A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With ObesityActive, not recruitingNCT07639021Phase 2Report a problem
• AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose WeightActive, not recruitingNCT07400107Phase 3Report a problem
• Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial)CompletedNCT07295223Phase 3Report a problem
• A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With ObesityActive, not recruitingNCT07285902Phase 3Report a problem
• Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have DiabetesActive, not recruitingNCT07284979Phase 3Report a problem
• UBT251 Injection Phase II (Type 2 Diabetes Mellitus) StudyCompletedNCT07163624Phase 2Report a problem
• A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)Active, not recruitingNCT07073417Phase 2Report a problem
• A Study of BGM0504 in Participants With Type 2 Diabetes in IndonesiaActive, not recruitingNCT07064486Phase 3Report a problem
• A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes MellitusActive, not recruitingNCT06982859Phase 1Report a problem
• A Study of BGM0504 in Chinese Patients With Type 2 DiabetesCompletedNCT06974825Phase 2Report a problem
• A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD）Active, not recruitingNCT06884293Phase 3Report a problem
• Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese AdultsActive, not recruitingNCT06827002Phase 1/2Report a problem
• A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes MellitusCompletedNCT06778967Phase 3Report a problem
• A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With ObesityActive, not recruitingNCT06745284Phase 1Report a problem
• A Study of BGM0504 in Participants With Type 2 DiabetesCompletedNCT06716216Phase 3Report a problem
• A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 DiabetesCompletedNCT06649344Phase 3Report a problem
• Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.CompletedNCT06579105Phase 2Report a problem
• Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)Active, not recruitingNCT06260722Phase 3Report a problem
• A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes MellitusActive, not recruitingNCT06256549Phase 2Report a problem
• A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and ObesityCompletedNCT06184568Phase 3Report a problem
• A Study of HS-20094 in T2DM ParticipantsCompletedNCT06118008Phase 2Report a problem
• A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)CompletedNCT05877547Phase 2Report a problem
• Gastric Sleeve-Induced Weight Loss on Shortness of Breath in ObesityWithdrawnNCT05812183Phase 4Report a problem
• Assessment of Safety, Tolerability and Drug Levels of Exenatide ImplantCompletedNCT05670379Phase 1Report a problem
• A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the LiverActive, not recruitingNCT05202353Phase 1Report a problem

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