Sapropterin: all 63 studies that test it

Page 1 of 1. Open to participants first (5), then studies with results posted, then the rest; newest registration first within each.

• A Single Patient Study of Sapropterin for Multisystem Smooth Muscle Dysfunction SyndromeNot yet recruitingNCT07574034Not applicable
• PD-1 Antibody and Sapropterin Dihydrochloride in Patients With PDACRecruitingNCT06396637Phase 2
• Novel Approaches for Improving Vascular Function in Veterans With HFpEFRecruitingNCT06312748Phase 1
• : Vascular Function in Health and DiseaseRecruitingNCT02966665Phase 1
• Neurovascular Transduction During Exercise in Chronic Kidney DiseaseRecruitingNCT02947750Phase 2
• Study on Sapropterin Dihydrochloride Oral Suspension in Healthy SubjectsCompletedNCT06481709Phase 1Results posted
• Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary DiseaseCompletedNCT02774226Phase 2Results posted
• Systemic Sclerosis (SSc) Vasculopathy: Improved Clinical Monitoring and TreatmentCompletedNCT02530996Phase 1/2Results posted
• Rhode Island Diastolic Dysfunction - Heart FailureCompletedNCT02353312Not applicableResults posted
• Sapropterin on Cognitive Abilities in Young Adults With PhenylketonuriaTerminatedNCT01977820Phase 2Results posted
• A Pilot Study on Diurnal VariationTerminatedNCT01806051Not applicableResults posted
• Cystic Fibrosis and Endothelial Function: At Rest and During ExerciseCompletedNCT01772758Phase 2Results posted
• Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With PhenylketonuriaCompletedNCT01732471Phase 3Results posted
• Kuvan in People With Schizophrenia and Schizoaffective DisorderCompletedNCT01706965Phase 1/2Results posted
• Effects of Kuvan on Melatonin SecretionCompletedNCT01617070Phase 4Results posted
• Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan TherapyTerminatedNCT01541397Not applicableResults posted
• Endothelial Facilitation in Alzheimer's DiseaseCompletedNCT01439555Phase 2Results posted
• Study of Kuvan Treatment in Adults With GTPCH DeficiencyCompletedNCT01425528Phase 1/2Results posted
• Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT01398943Not applicableResults posted
• Phenylketonuria, Oxidative Stress, and BH4TerminatedNCT01395394Phase 2Results posted
• Kuvan® in Phenylketonuria Patients Less Than 4 Years OldCompletedNCT01376908Phase 3Results posted
• Exercise Intolerance in Renal FailureCompletedNCT01356966Phase 2Results posted
• Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental DisordersCompletedNCT01141595Not applicableResults posted
• Impact of KUVAN® on Gastric Relaxation in Women With Diabetic Gastroparesis.CompletedNCT01135186Not applicableResults posted
• Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) PatientsCompletedNCT01114737Phase 3Results posted
• Response to Kuvan® in Subjects With Phenylketonuria (PKU) in a 4 Weeks Testing PeriodCompletedNCT01082328Phase 4Results posted
• Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN TherapyCompletedNCT00986973Not applicableResults posted
• Open-Label Extension Study of Kuvan for AutismCompletedNCT00943579Phase 2/3Results posted
• Sapropterin as a Treatment for Autistic DisorderCompletedNCT00850070Phase 2Results posted
• Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan ResponseCompletedNCT00841100Phase 2Results posted
• Effect of Kuvan on Neurocognitive Function, Blood Phenylalanine Level, Safety, and Pharmacokinetics in Children With PKUCompletedNCT00838435Phase 3Results posted
• Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial DysfunctionTerminatedNCT00802893Phase 2Results posted
• Tetrahydrobiopterin in Patients With Chronic Kidney Disease (CKD) and AlbuminuriaCompletedNCT00625820Phase 2Results posted
• A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial DysfunctionCompletedNCT00532844Phase 2Results posted
• A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell DiseaseCompletedNCT00445978Phase 2Results posted
• A Phase 2 Study of the Effects of Sapropterin Dihydrochloride on Symptomatic Peripheral Arterial DiseaseCompletedNCT00403494Phase 2Results posted
• Study of Phenoptin in Subjects With Phenylketonuria Who Participated in Protocols PKU-004 or PKU-006CompletedNCT00332189Phase 3Results posted
• Study of Phenoptin to Increase Phenylalanine Tolerance in Phenylketonuric Children on a Phenylalanine-restricted DietCompletedNCT00272792Phase 3Results posted
• Study to Evaluate the Safety and Efficacy of Phenoptin™ in Subjects With Phenylketonuria Who Have Elevated Phenylalanine LevelsCompletedNCT00104247Phase 3Results posted
• Evaluation of BH4 Responsiveness in Our PKU PatientsActive, not recruitingNCT07255599Phase 1
• BH4 in the Prevention and Treatment of Radiation-induced Skin Reactions for Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)Status unknownNCT05299203Phase 1
• A Study for Assessing the Efficacy and Safety of BH4 in Radiation EnteritisStatus unknownNCT05138887Phase 2
• A Study for Assessing the Efficacy and Safety of Tetrahydrobiopterin in Radiation-Induced Skin InjuryStatus unknownNCT05114226Phase 1
• The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent ClaudicationActive, not recruitingNCT04800692Phase 1
• BH4 Responsiveness in PAH Deficiency PKU PatientsStatus unknownNCT04227080Phase 4
• O2 Transport and Utilization in Health and Lung DiseaseWithdrawnNCT04014712Phase 1
• The Effect of Antioxidants on Skin Blood Flow-BH4CompletedNCT03680573Phase 1
• Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery DiseaseWithdrawnNCT03493412Phase 4
• Exercise and NO in HFrEFCompletedNCT03136029Early Phase 1
• Kuvan®'s Effect on the Cognition of Children With PhenylketonuriaCompletedNCT01965912Phase 4
• Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal HypertensionCompletedNCT01456286Phase 2/3
• Neuroimaging and Neurocognitive Assessment and Response to Sapropterin Dihydrochloride Treatment in PhenylketonuriaWithdrawnNCT01412437Not applicable
• Trial of Kuvan in Lesch-Nyhan DiseaseWithdrawnNCT00935753Phase 2/3
• A Phase 1 Study to Evaluate Effects of Sapropterin Dihydrochloride on QTc Intervals in Healthy Adult SubjectsCompletedNCT00789568Phase 1
• 6R-BH4 Pulmonary Arterial Hypertension StudyCompletedNCT00435331Phase 1
• Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and SafetyTerminatedNCT00432822Phase 2/3
• Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)Status unknownNCT00423280Phase 2
• A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic HypertensionCompletedNCT00325962Phase 2
• Study of BH4, a New and Simple Treatment of Mild PKUCompletedNCT00260000Phase 2
• Response to Phenylketonuria to Tetrahydrobiopterin (BH4)TerminatedNCT00244218Phase 1
• A Phase 3, Multicenter, Open-Label Extension Study of Phenoptin in Subjects With PKU Who Have Elevated Phenylalanine LevelsCompletedNCT00225615Phase 3
• Effects of Tetrahydrobiopterin on Blood PressureCompletedNCT00208780Early Phase 1
• Study to Evaluate the Response to and Safety of an 8-Day Course of Phenoptin™ Treatment in Subjects With PhenylketonuriaCompletedNCT00104260Phase 2

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