Ivonescimab: all 132 studies that test it
Page 1 of 2. Open to participants first (111), then studies with results posted, then the rest; newest registration first within each.
- Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural MesotheliomaRecruitingNCT07885319Phase 1/2
- A Clinical Study of Ivonescimab in Combination With Cadonilimab or Ipilimumab for Advanced Renal CancerNot yet recruitingNCT07877194Phase 2
- A Phase II Study of Ivonescimab in Combination With GEMOX as Neoadjuvant and Conversion Therapy for Biliary Tract CancerRecruitingNCT07854600Phase 2
- Paclitaxel Polymeric Micelles Plus Ivonescimab in Recurrent or Refractory SCLCNot yet recruitingNCT07819591Phase 2
- AK112 Combined With GAP Conversion Therapy for Locally Advanced Gallbladder CancerNot yet recruitingNCT07767994Phase 2
- Testing the Addition of Ivonescimab Combined With Standard Chemotherapy Compared to the Usual Chemotherapy and Immunotherapy Treatment for Patients With Advanced Biliary Tract CancerNot yet recruitingNCT07765433Phase 2/3
- A Phase II Study of Ivonescimab Combined With Intraperitoneal Paclitaxel in Patients With High-Grade Metastatic Appendiceal Adenocarcinoma (AA)Not yet recruitingNCT07753824Phase 2
- STOMP OUT: A Phase 2 Study To Evaluate The Effects Of Ivonescimab In Patients With Unresectable/Metastatic Adrenocortical Carcinoma (ACC) Or Unresectable Pheochromocytoma/Paraganglioma (PPGL)Not yet recruitingNCT07743138Phase 2
- Phase II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of ALK201 for Injection in Combination With Ivonescimab Injection in sqNSCLC Participants.Not yet recruitingNCT07742956Phase 2
- A Phase II Study of AK146D1 in Combination With AK112 in Advanced Non-Small Cell Lung CancerRecruitingNCT07669779Phase 2
- Pilot Study of Ivonescimab in Advanced/Metastatic Cutaneous AngiosarcomaRecruitingNCT07655570Phase 2
- OVV-01 Intravenous and Intratumoral Injection Combined With AK112 for the Treatment of Advanced Solid TumorsNot yet recruitingNCT07650825Phase 1
- Trastuzumab Deruxtecan Plus ivonescImab for Hormone Receptor-positive HER2 Negative Advanced Breast Cancer StudyRecruitingNCT07647016Phase 2
- A Phase II Study of AK146D1 Mono or Combined With AK112 in Advanced Urothelial CarcinomaNot yet recruitingNCT07636772Phase 2
- Trastuzumab Rezetecan(SHR-A1811) Combined With Ivonescimab (AK112) in Locally Advanced or Metastatic Non-small Cell Lung Cancer Harboring HER2 Gene AbnormalitiesNot yet recruitingNCT07630077Phase 2
- A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Non-Small Cell Lung CancerRecruitingNCT07623356Phase 1/2
- A Study of Tepotinib and Ivonescimab in People With Non-Small Cell Lung CancerRecruitingNCT07619339Phase 1
- Evaluate the Safety, Tolerability, and Preliminary Efficacy of EVM14 in Combination With Ivonescimab in Sq-NSCLC PatientsNot yet recruitingNCT07614646Phase 1
- A Study of Risvutatug Rezetecan in Combination With Ivonescimab in Participants With Advanced Solid Tumors (EMBOLD PanTumour-103)RecruitingNCT07602855Phase 1/2
- A Study of Ivonescimab in People With Non-Small Cell Lung CancerRecruitingNCT07594522Phase 1/2
- A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast CancerRecruitingNCT07591090Phase 2
- AMT-116 in Combination With AK112 in Patients With Lung CancerRecruitingNCT07590531Phase 1/2
- Evaluating Ivonescimab in PD-1 Resistant Recurrent or Metastatic Nasopharyngeal CarcinomaNot yet recruitingNCT07565389Phase 2
- A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Breast CancerNot yet recruitingNCT07560124Phase 1/2
- A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung CancerRecruitingNCT07535463Phase 1/2
- A Study of Ivonescimab in People With LeiomyosarcomaRecruitingNCT07516925Phase 2
- SHR-A1811 + AK112 in HER2-Altered Advanced/Metastatic NSCLCNot yet recruitingNCT07489703Phase 2
- Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)RecruitingNCT07472478Phase 2
- ctDNA-guided Treatment Decision-makingRecruitingNCT07394218Phase 2
- Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial)RecruitingNCT07393555Phase 2
- A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCCRecruitingNCT07385001Phase 1/2
- Perioperative Ivonescimab Plus S-1 and Oxaliplatin (SOX) for Locally Advanced Gastric or GEJ AdenocarcinomaNot yet recruitingNCT07374250Phase 2
- Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver MetastasesNot yet recruitingNCT07359456Phase 2
- Glecirasib Combined With Ivonescimab for First-line Treatment of KRAS G12C-mutated NSCLCNot yet recruitingNCT07339839Phase 1/2
- Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHNRecruitingNCT07264075Phase 3
- Ivonescimab Monotherapy or in Combination With Chemotherapy as Neoadjuvant/Adjuvant Therapy for Resectable Non-small Cell Lung CancerNot yet recruitingNCT07241819Phase 2
- A Trial Evaluating the Efficacy of Ivonescimab in Metastatic Endocrine Refractory HR-positive HER2-negative or Triple Negative Invasive Lobular CarcinomaRecruitingNCT07229417Phase 2
- Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal CancerRecruitingNCT07228832Phase 3
- Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell CancerRecruitingNCT07226544Phase 2
- A Study of YL201 and Ivonescimab (AK112) in Advanced Solid TumorsRecruitingNCT07208773Phase 1/2
- The IVO-LUNG StudyNot yet recruitingNCT07204548Phase 2
- Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell CarcinomaRecruitingNCT07188103Phase 2
- SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal CancerRecruitingNCT07162714Phase 2
- AK112 in Non-squamous Non-small Cell Lung Cancer (NSCLC)Patients With Actionable Genomic Alterations (AGA) Who Have Failed to Previous Tyrosine Kinase Inhibitor (TKI) TreatmentNot yet recruitingNCT07158840Phase 2
- Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLCRecruitingNCT07158489Phase 2
- Prospective Multicenter Single-arm Trial: AK112 + Nab-paclitaxel/Carboplatin Neoadjuvant for TNBCNot yet recruitingNCT07103447Phase 2
- Ivonescimab (PD-1/VEGF Bispecific Antibody) Plus Radiofrequency Ablation for Multiple Advanced Tumors After PD-1 Therapy FailureNot yet recruitingNCT07095803Phase 2
- Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck CancerRecruitingNCT07094685Phase 2
- Efficacy and Safety of AK112 Combined Chemotherapy as Neoadjuvant Treatment for Signet Ring Cell-containing G/GEJ AdenocarcinomaNot yet recruitingNCT07091227Phase 2
- A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLCNot yet recruitingNCT07086326Phase 2
- Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II TrialRecruitingNCT07070479Phase 2
- Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEARecruitingNCT07070466Phase 2
- Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung CancerRecruitingNCT07057791Phase 2
- A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.RecruitingNCT07052253Phase 2
- AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal CancerNot yet recruitingNCT07021950Phase 2
- Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast CancerRecruitingNCT07017673Phase 2
- A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation TherapyRecruitingNCT07010263Phase 3
- Phase II Study of Platinum (Cisplatin/Carboplatin)and Polymeric Micelles Paclitaxel(Pm-Pac) With Ivonescimab in First Line Metastatic Squamous NSCLC.Not yet recruitingNCT07009925Phase 2
- Ivonescimab in Combination With Liposomal Irinotecan and 5-FU/LV in Potentially Resectable Biliary Tract MalignanciesNot yet recruitingNCT06993025Phase 2
- Ivonescimab for the Treatment of Thymic CancerRecruitingNCT06980077Phase 2
- Neoadjuvant Therapy With Ivonescimab Combined With Chemotherapy for Triple-Negative Breast CancerNot yet recruitingNCT06977542Phase 2
- Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal CancerRecruitingNCT06959550Phase 2
- A Phase III Study of Ivonescimab + Chemo With/Without AK117 in Metastatic Pancreatic CancerRecruitingNCT06953999Phase 3
- ctDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)RecruitingNCT06951646Phase 2
- AK112 and Chemotherapy in First-line Metastatic Colorectal CancerRecruitingNCT06951503Phase 3
- A Study on Ivonescimab Plus Chemotherapy as Neoadjuvant Therapy for Borderline Resectable Pancreatic CancerRecruitingNCT06944106Phase 2
- Phase II Trial of Ivonescimab in Previously Treated Patients With Advanced Clear Cell Renal Cell CarcinomaRecruitingNCT06940518Phase 2
- A Multicenter, Single-arm Phase II Study to Evaluate the Efficacy and Safety of Fulzerasib (IBI351) in Combination With Ivonescimab (AK-112) in First-line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer Patients With KRAS G12C MutationNot yet recruitingNCT06936644Phase 2
- A Prospective, Single Arm, Open Label, Phase II Clinical Study on the Efficacy and Safety of Ivonescimab (AK112) Combined With TAS-102 in the Treatment of Refractory MSS/pMMR Advanced Colorectal CancerEnrolling by invitationNCT06936488Not applicable
- A Study of AK112, a PD-1/ VEGF Bispecific Antibody, for Resectable Hepatocellular Carcinoma With High Recurrence RiskRecruitingNCT06930573Phase 4
- Ivonescimab in Combination With Docetaxel in Advanced Non-Small Cell Lung CancerRecruitingNCT06928389Phase 3
- A Study of Ivonescimab in People With Endometrial and Cervical CancersRecruitingNCT06925724Phase 2
- A Study of mRNA Vaccines AK154 Monotherapy or in Combination With AK104/AK112,and Sequential mFOLFIRINOX in Surgically Resected PDACNot yet recruitingNCT06913218Phase 1
- Ivonescimab (AK112) Plus Paclitaxel as Second-line Therapy in Patients With Advanced G/GEJ CancerNot yet recruitingNCT06904300Phase 2
- Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural MesotheliomaRecruitingNCT06875076Phase 2
- Ivonescimab Plus Chemotherapy in Patients With Initially Unresectable Colorectal Cancer Liver MetastasesRecruitingNCT06848842Phase 2
- Adapted Guided Stereotactic Body Radiotherapy Combined With Chemotherapy and Enhancement of Novel Drug Ivonescimab for Pancreatic Cancer (ASCEND)RecruitingNCT06844422Phase 1/2
- Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and ChemotherapyRecruitingNCT06840834Phase 2
- Neoadjuvant Ivonescimab and Chemotherapy in Resectable Esophageal CancerNot yet recruitingNCT06814158Phase 2
- Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06814067Phase 2
- A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland CancersRecruitingNCT06805617Phase 2
- Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal CancerRecruitingNCT06802666Phase 2
- Low-dose Radiotherapy Combined With Chemotherapy and AK112 as Second-line Treatment in Patients With Advanced G/GEJ CancerRecruitingNCT06791148Phase 2
- Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon CancerNot yet recruitingNCT06790212Phase 2
- Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLCRecruitingNCT06769971Phase 2
- A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLCRecruitingNCT06769295Phase 2
- AK112 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/ Metastatic Triple-negative Breast CancerRecruitingNCT06767527Phase 3
- Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1RecruitingNCT06767514Phase 3
- Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIsNot yet recruitingNCT06766591Not applicable
- Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal CancerNot yet recruitingNCT06760520Phase 2
- Ivonescimab Combined with Chemotherapy As First-line Treatment of Relapsed or Metastatic Thymic Cancer: a Prospective, Single Arm, Phase II TrialNot yet recruitingNCT06750952Phase 2
- Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian CancerRecruitingNCT06686030Phase 2
- A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)Not yet recruitingNCT06684873Phase 2
- A Phase I/II Study of IVONESCIMAB in Recurrent GlioblastomaRecruitingNCT06672575Phase 1/2
- Phase II Clinical Trial of Chidamide Combined With AK112 for Second-line and Advanced Bone and Soft Tissue SarcomaRecruitingNCT06637007Phase 2
- Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell CarcinomaRecruitingNCT06567314Phase 2
- An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian CancerRecruitingNCT06560112Phase 2
- AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell CarcinomaNot yet recruitingNCT06537011Phase 2
- A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC)RecruitingNCT06530251Phase 1/2
- Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer PatientsRecruitingNCT06529718Phase 2