Spinocerebellar Degenerations clinical trials
The registry lists 49 studies for Spinocerebellar Degenerations across more than 10 countries. 15 are recruiting or about to start. 29 of them are mainly about Spinocerebellar Degenerations (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 4 narrower conditions too, such as Friedreich Ataxia: 295 studies, 69 open.
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Who runs them
Kissei Pharmaceutical Co., Ltd. (9) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · Second Affiliated Hospital, School of Medicine, Zhejiang University (3) · Universitat de Lleida (2) · Bristol-Myers Squibb (2) · Columbia University (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Merck Sharp & Dohme LLC (2)
What is being tested here
Drugs under test in Spinocerebellar Degenerations studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Bevacizumab | 1 | 0 | 2 |
| Iparomlimab/Tuvonralimab | 1 | 1 | 1 |
| Xelox | 1 | 0 | 1 |
| Porustobart | 1 | 0 | 1 |
| Ipilimumab N01 | 1 | 0 | 1 |
| Sintilimab | 1 | 0 | 1 |
| Ipilimumab | 1 | 0 | 1 |
| Rovatirelin | 0 | 6 | 9 |
| Nivolumab | 0 | 1 | 2 |
| Pembrolizumab | 0 | 0 | 2 |
Drug classes tested here Immune checkpoint inhibitors 5 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Mar 2027Confirmatory Study 3 of KPS-0373 in Patients With Spinocerebellar Degeneration · Phase 3 · Kissei Pharmaceutical Co., Ltd.
- Feb 2027SBRT Combined With CAPEOX, Bevacizumab, and PD-1 Inhibitor for the Treatment of RAS-Mutant, MSS-Type, Unresectable Metastatic Colorectal Cancer. · The First Affiliated Hospital with Nanjing Medical University
- Oct 2027A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors · Bristol-Myers Squibb
Who these studies take
Of the 9 Spinocerebellar Degenerations studies recruiting now, 5 (56%) set no upper age limit and 3 (33%) stop at 75 or younger. 4 (44%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (44%) | 4 (44%) |
| 18 | 8 (89%) | 8 (89%) |
| 30 | 9 (100%) | 9 (100%) |
| 40 | 9 (100%) | 9 (100%) |
| 50 | 9 (100%) | 9 (100%) |
| 65 | 8 (89%) | 8 (89%) |
| 75 | 6 (67%) | 6 (67%) |
| 85 | 6 (67%) | 6 (67%) |
Across all 49 studies, recruiting or not: 16% stop at 75 or younger and 12% at 65; 18% take children; 0% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
- Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon CancerOct 22, 2026NCT07808151
Studies
Recruiting first, then most recently updated. Showing 49 of 49. search them.
- Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon CancerRecruitingNCT07808151Phase 26 countries
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- Phenotype/Genotype Correlations in Movement DisordersRecruitingNCT000188891 country
- TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic AtaxiasRecruitingNCT077986749 countries
- A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HDRecruitingNCT05822908Phase 1/26 countries
- FOLFIRI Plus Bevacizuamb and QL1706 in Second-Line Treatment for mCRCNot yet recruitingNCT07729605Phase 31 country
- SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal CancerNot yet recruitingNCT07551479Phase 31 country
- A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal CancerRecruitingNCT07506109Phase 21 country
- Telerehabilitation for Core Stability and Strength in Hereditary AtaxiaNot yet recruitingNCT07200505Not applicable1 country
- Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS)Not yet recruitingNCT07079332
- Hereditary Ataxia Research on Multi-Omics and Neuroclinical Insights in the Yangtze DeltaRecruitingNCT070923581 country
- SBRT Combined With CAPEOX, Bevacizumab, and PD-1 Inhibitor for the Treatment of RAS-Mutant, MSS-Type, Unresectable Metastatic Colorectal Cancer.Not yet recruitingNCT06835179Phase 2
- Node-Sparing Short-Course Radiation with CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: a Randomized, Prospective, Multicenter StudyNot yet recruitingNCT06594692Phase 21 country
- Genotype-phenotype Correlation and Pathogenic Mechanism in Hereditary AtaxiaRecruitingNCT051608701 country
- Neuroimaging Changes in Hereditary AtaxiaRecruitingNCT051608831 country
- Confirmatory Study 3 of KPS-0373 in Patients With Spinocerebellar DegenerationActive, not recruitingNCT07040137Phase 31 country
- A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal CancerTerminatedNCT05328908Phase 322 countries
- A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid TumorsActive, not recruitingNCT06544655Phase 13 countries
- Efficacy of tDCS in Degenerative AtaxiaActive, not recruitingNCT07250321Not applicable1 country
- Trial of Atezolizumab, Bevacizumab, and Tiragolumab in Patients With Microsatellite Stable, Metastatic Colorectal CancerActive, not recruitingNCT06784947Phase 21 country
- Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal CancerCompletedNCT03711058Phase 1/21 country
- Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal CancerCompletedNCT03642067Phase 21 country
- Telerehabilitation, Core Stability Exercises and Hereditary Ataxia (TRCore-ataxia)CompletedNCT06152133Not applicable1 country
- Study of MK-3475 (Pembrolizumab) in Patients With Microsatellite Unstable (MSI) Tumors (Cohort D)CompletedNCT04098068Phase 21 country
- Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar AtaxiaCompletedNCT00202397Phase 21 country
- Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC) (MK-7690-046)CompletedNCT03631407Phase 22 countries
- Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651)CompletedNCT03374254Phase 12 countries
- A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin LymphomaTerminatedNCT03207867Phase 215 countries
- AN0025 and Pembrolizumab Combination in Advanced Solid TumorsActive, not recruitingNCT04432857Phase 12 countries
- C-Trelin Orally Disintegrated(OD) Tablet 5mg in Ataxia Due to Spinocerebellar DegenerationCompletedNCT04107740Phase 41 country
- Core Stability Exercises and Hereditary AtaxiaCompletedNCT04750850Not applicable1 country
- Functional Trunk Training in Ataxia PatientsCompletedNCT04740359Not applicable1 country
- Ataxia and Exercise Disease Using MRI and Gait AnalysisCompletedNCT03701776Not applicable1 country
- Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative AtaxiaCompletedNCT03120013Not applicable1 country
- Aerobic Exercise, Balance Training, and AtaxiaCompletedNCT03745248Not applicable1 country
- A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01970098Phase 31 country
- An Additional Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT02889302Phase 31 country
- Epacadostat in Combination With Pembrolizumab and Azacitidine in Subjects With Metastatic Colorectal CancerWithdrawnNCT03182894Phase 1/21 country
- A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01970124Phase 31 country
- A 24-week Open-label Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01970137Phase 31 country
- An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01970111Phase 31 country
- Phenotypic and Genotypic Studies in Congenital and Early Onset AtaxiasCompletedNCT014884611 country
- A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01384435Phase 21 country
- Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary AtaxiaStatus unknownNCT01360164Phase 1/21 country
- A New Method to Treat Hereditary Cerebellar Ataxia - Umbilical Cord Mesenchymal Stem Cells TransplantationStatus unknownNCT01489267Phase 21 country
- Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10)CompletedNCT000043061 country
- A Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT01004016Phase 21 country
- Phase II Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)CompletedNCT00863538Phase 21 country
- High-Dose Intravenous Immunoglobulin to Treat Cerebellar DegenerationCompletedNCT00034242Phase 21 country